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In vivo studies in Apc min/+ mice demonstrated that deoxycholic acid (DCA) promotes the adenoma-adenocarcinoma transition and DCAinduced changes to the microbial community promoted intestinal carcinogenesis (127, 128)

SLD was defined as the presence of hepatic steatosis identified on ultrasound

Logistic regression analysis indicated that, in buffer, the concentration corresponding to a 50% probability of detection (LOD) was 5.2 ng/mL (95% CI: 4.65.8 ng/mL), and in serum it was 6.1 ng/mL (95% CI: 5.56.8 ng/mL)

Sustained Daily Signaling Some injuries respond better to consistent daily repair signaling over weeks than to a single large dose