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Collectively, these interconnected mechanisms cooperatively compromise the glomerular filtration barriers permselectivity and podocyte architecture, leading to escalating albuminuria, progressive tubulointerstitial scarring, and the eventual onset and advancement of diabetic nephropathy

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Near the critical pressure, the effect of fluid density is predominant, thus, a moderate increase in temperature leads to a large decrease in the fluid density, and therefore, to a decrease in solute solubility