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This mechanism underpins benefits spanning energy, endurance, and metabolic flexibility that support healthy ageing

3.1 T1D-associated genes: impact on immune function Approximately 40-50% of the genetic risk of developing T1D is attributed to the class I and II MHC/HLA region, with class II being the most significant, as it is essential to the adaptive immune system ( Figure 1 ) (50)

Molecular profiling has shown that exercise upregulates genes involved in ATP production and lysosomal regulation in immature neurons, contributing to neuronal resilience [293]