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Contrary to mammalian mitochondria yeast mitochondria are like plant mitochondria which oxidize cytosolic NADH directly (Zhao et al., 2020)

Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking

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