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Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]

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These findings suggest that vitamin D deficiency may act as both a consequence and a mediator of circadian misalignment, potentially compounding the carcinogenic effects of LAN exposure and reinforcing the need to consider vitamin D status in risk stratification and prevention strategies for NSW-exposed individuals 250

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