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The ascorbate peroxidase-glutathione reductase (APX-GR) system is far efficient in detoxification of hydrogen peroxide (H 2 O 2 ) than catalase (CAT) and peroxidase (POD) and the exogenous addition of ascorbate through the nutritional solution was reported to result in marked reduction in the activities of both enzymes (Dolatabadian and Jouneghani, 2 O 2 is widely discussed (Bray et al., 2005) investigated the relationship of glutathione and AsA concentrations in the activation of plant innate stress responses through antioxidative metabolism and it was concluded that elevated levels of glutathione, its reduced form, and ascorbate deficiency triggers salicylic acid (SA) mediated signaling that is independent of H 2 O 2

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TABLE 1 Current clinical trials for therapeutic agents for the treatment of ALD