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Mach KE, Mohan R , Patel S, Wong PK, Hsieh M, Liao JC

By using senolytics to remove senescent endothelial and smooth muscle cells, combined with senomorphics like rapamycin to modulate the SASP, this dual approach could reduce arterial stiffness, improve vascular function, and lower the risk of heart attacks and stroke.211,212 Neurodegenerative Diseases: Conditions like Alzheimers disease, Parkinsons disease, and other forms of dementia are characterized by neuroinflammation and the accumulation of senescent cells in the brain.26 Combination therapies targeting both senescent cells and the neuroinflammatory SASP could slow disease progression, improve cognitive function, and promote neuronal repair.213 Senolytics like dasatinib and quercetin, combined with senomorphic agents such as NMN, could help rejuvenate neuronal tissue and prevent cognitive decline.214 Osteoporosis and Sarcopenia: Aging is associated with a decline in bone density and muscle mass, partly driven by the accumulation of senescent cells in bone and muscle tissue

The results suggest that the intake of vitamin E, vitamin B6, and niacin may be potentially associated with a reduced risk of gallstones

McGregor, M