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BMC Pregnancy and Childbirth (2025) 25:1120 Table 2 Ovarian stimulation characteristics and pregnancy outcomes Low Average High P value Dosage of Gn (IU) 2646.43 933.92 2325.44 867.31&1 2353.34 885.07&2 0.01 Duration of Gn (days) 11.69 1.65 11.50 1.85 11.54 1.57 0.661 FSH value on trigger day (mIU/mL) 16.45 5.95 15.21 4.55 15.74 6.07 0.236 E2 value on trigger day (pg/ml) 2172.06 965.30 2272.20 980.56 2526.51 1202.85 0.068 LH value on trigger day (mIU/mL) 0.93 0.49 0.89 0.42 1.00 0.54 0.267 P value on trigger day (ng/ml) 0.68 0.37 0.76 0.43 0.77 0.38 0.186 No

The same 4 mg daily sublingual dose will produce different circulating drug concentrations in a 150-pound person versus a 300-pound person due to differences in volume of distribution

Hawkins LC, Edwards JN, Dargan PI

Supplements taken orally, such as capsules and tablets, are the most common type, but their main disadvantage is their presumed ineffectiveness.