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Description

By increasing intracellular DAG, lipin-1 links lipid synthesis to pro-inflammatory signaling

Dysregulation of CTR1 and ATP7A/B, whether through altered expression (e.g., CTR1 downregulation in drug-resistant tumors) or genetic mutations, disrupts copper homeostasis and impairs drug accumulation

Acknowledgments This study received financial support from Fundao de Amparo a Pesquisa de Gois (FAPEG), Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), and Conselho Nacional do Desenvolvimento Cientfico e Tecnolgico (CNPq)

A diferencia de las variantes modificadas con DAC, la forma Sin DAC se caracteriza por una ventana de actividad ms corta, lo que la convierte en un punto de inters en estudios sobre la dinmica de los pulsos endgenos de la hormona del crecimiento y los mecanismos de retroalimentacin regulatoria