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Simultaneously, the IRAK-TRAF6 complex activates mitogen-activated protein kinase kinase (MKK) cascades, thus leading to activation of activator protein 1 (AP-1), which is another critical transcription factor in inflammation (50)

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Further analysis revealed that the DEGs, particularly those genes within the PPAR signaling pathway with upregulated expression, such as angiopoietin-like 4 ( ANGPTL4 ), CD36 , FATP1 , fatty acid transport protein 4 ( FATP4 ), and perilipin 2 ( PLIN2 ) in the leg muscles of caged versus free-range Lueyang black-boned chickens, are associated with IMF deposition (Table 1) [56]