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In contrast, testosterone cypionate has a longer half-life of approximately 8 days, allowing it to provide a sustained testosterone release over a week or more

Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations

Injection site reactions Redness, mild swelling, itching, or small nodules at the injection site occurred in 5 to 15% of trial participants