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Taiba J

doi:10.1016/j.mam.2009.01.001, PMID: 19232542 Markovic J, Garca-Gimenez JL, Gimeno A, Via J, Pallard FV (2010) Role of glutathione in cell nucleus

For example, Legionella pneumophila secretes the effector SdhA, which maintains mitochondrial integrity and limits mtDNA leakage, helping the bacterium to avoid immune hyperactivation ( Beyond the cGAS-STING and NLRP3 inflammasome pathways, mtDNA also serves as a ligand for endosomal TLR9, which recognizes unmethylated CpG motifs in bacterial and mitochondrial DNA (Tripathi et al., 2023)