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In many of the above studies, patients were reported to have subnormal B12 levels

Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the PreissHandler pathway

In a second work (127), the authors investigated the role of crocetin, a component of saffron stigma, which has significant therapeutic effects on various diseases, including cancers