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Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y

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Clark, S., et al

The biological context in which a patient is exposed to PBDE from within the environment and PDBE is processed by the placenta and its direct metabolites and other factors (growth, cytokines/chemokines, etc