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Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptoragonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing.Neuropharmacol 2005

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doi: 10.1084/jem.20070590 45 HallJACannonsJLGraingerJRDos SantosLMHandTWNaikSet al

Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]