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However, the CNS is particularly vulnerable to oxidative stress because of the abundance of readily oxidizable substances, limited levels of primary and secondary antioxidants, elevated iron content in specific brain regions, the generation of ROS by various internal mechanisms, and the presence of non-replicating neurons (Maher, 2006

Pathak, "Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging," Baylor College of Medicine, 2013

Effective treatments are essential to mitigate the adverse health outcomes associated with MUD

doi: 10.1016/j.plaphy.2016.02.001 244 XuJ