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Similarly, overexpression of OsTHI7 in rice decreased susceptibility to Pythium graminicola colonization (Ji et al., 2015)

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However, in rats, tiotropium caused fetal resorption, litter loss, decreases in the number of live pups at birth and the mean pup weights, and a delay in pup sexual maturation at tiotropium doses of approximately 40 times the MRHDID (on a mcg/m2 basis at a maternal inhalation dose of 78 mcg/kg/day)