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The success of GLP-1 agonists in clinical practice has validated the concept that pharmacological approaches to obesity are effective but it has also highlighted their limitations

Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug

It is a tool that supports metabolic function and, when combined with appropriate diet and exercise, can enhance fat loss outcomes

No Human Adverse-Event Programme Without a controlled clinical development programme, the frequency and severity of possible adverse reactions cannot be estimated reliably