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These trials could provide valuable insights into the effectiveness of targeting oxidative stress and mitochondrial dysfunction as a therapeutic strategy in these conditions

doi: 10.1080/13102818.2020.1837011 92 SinghA.MehtaS.YadavS.NagarG.GhoshR.RoyA.et al

also known as alanine, serine, cysteine-preferring transporter 2, ASCT2), and then convert it into glutamate under the action of glutaminase (GLS), and further convert it into -ketoglutarate (-KG), which enters the Tricarboxylic Acid cycle (TCA) and participates in the onset, development and dissemination of tumors [21, 22]

In parallel, large-animal studies have reported that epicardial EHT allografts support long-term engraftment, vascular integration, and recovery of ventricular function in rhesus macaques without inducing arrhythmias or tumorigenesis, further reinforcing clinical feasibility and highlighting critical translational considerations, including graft maturity, immune modulation, and Good Manufacturing Practice (GMP)-scale production 33