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Although the human body can produce glutathione on its own, production can have difficulty keeping up in times of excess stress, immune challenges, unhealthy microbial environments, or during aging, as glutathione status can decline with the natural aging process

In cases of moderate dehydration, oral rehydration solutions containing electrolytes may be necessary to restore balance

However, regular use over several days or weeks may be necessary for therapeutic advantages such tissue healing or inflammation reduction

The protein expression of individual GST isoforms may follow a different trend in MASLD progression