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During the oxidation of hydrogen sulfide, SQOR generates elemental sulfur (S 0 ), which can react with intracellular thiols, such as GSH, to form GSH persulfide (GSSH) or thiosulfate 97

2.5 Bone marrowderived macrophages Bone marrow cells from C57BL/6 and MyD88 -/- mice were obtained by washing the femurs and tibias with cold PBS and the stem cells were cultured in petri dishes in the presence of DMEM (Gibco) with 10% FBS, 1% HEPES, penicillin G sodium (100 U/ml), streptomycin sulfate (100 g/ml), and 20% L929 cell conditioned medium (LCCM) containing macrophage colony-stimulating factor (M-CSF)

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Conclusion: Our study reveals that CHB patients with the heterozygous LOXL1 G153D mutation tend to exhibit limited regression after HBV clearance