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Female mice exhibited greater disruption of grooming behavior, consistent with higher depression prevalence in women [60, 61], whereas males showed more pronounced anxiety-like behaviors, a divergence that may reflect sex differences in symptom expression or healthcare utilization, with males potentially underreporting or avoiding treatment for anxiety [62]

Its use outside of controlled research settings carries inherent risks related to compound purity, dosing accuracy, and the absence of the clinical safety monitoring that accompanies approved medications

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A study in the Journal of Clinical Endocrinology and Metabolism found that combined GH and testosterone administration in older men produced greater improvements in lean body mass and fat reduction than either hormone alone (Giannoulis et al., 2006)