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In addition, BHB acts as an endogenous ligand of HCA2

Contrasting meta-analyses suggested otherwise

2019 Apr 18;10(1):1812 [Abstract] Redox Biol

Moreover, a key challenge is balancing the desired anti-tumor immune effects with potential systemic metabolic side effects, such as dyslipidemia, which has been observed with some FXR agonists (132)