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Besides their role in brain development, astrocytic processes extensively ensheath synapses and participate in neurotransmitter removal from the synaptic cleft, preventing excitotoxicity and direct contact of the neurotransmitter with neighboring synapses

For example, caffeine, as an approved drug for clinical use, has anti-inflammatory and neuroprotective effects, and its mechanism of action is oxidative stress and inflammatory response

To understand the impact of PPARA upregulation in downstream metabolic processes in our system, we assayed the lipid accumulation, fatty acid -oxidation and lipid peroxidation in the BWS-iPSC differentiated hepatocytes and found changes in all examined lipid metrics in BWS hepatocytes