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In addition, Src-dependent Cav-1 phosphorylation is a crucial process mediating caveolae-associated endocytosis and eNOS activation in vascular endothelial cells 24,25

J Physiol Pharmacol 2010

This means the 10 to 200 mcg/kg doses that dominate the animal literature translate to a rough human equivalent of approximately 1.6 to 32 mcg/kg, or about 120 to 2,400 micrograms for a 75-kilogram adult