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Figure 3 In the CNS, dysbiosis directly or indirectly modulates the function of microglia and astrocytes via metabolites including SCFAs

The current medical treatment of choice for hypothyroidism is hormone replacement therapy with the drug levothyroxine (Synthroid [Knoll Pharm Co, Mt Olive, NJ]), which contains a synthetic version of T4

The upregulated urea cycle removes -amyloid and ammonia on one hand, while on the other, overproduction of the urea cycle metabolite ornithine leads to the overexpression of the enzyme ornithine decarboxylase 1 (ODC1), which produces excessive putrescine that subsequently degrades into GABA, H 2 O 2 and ammonium (see previous section)