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Also, 12% of lung adenocarcinoma (LUAD) samples display gene amplifications in NKX21, driving its overexpression [19, 20]

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Gomes AP, et al

More importantly, Nrf2 gene knockout inhibited the antifibrotic effect of AS-IV by downregulating the p-Smad3L/PAI-1 pathway and upregulating the p-Smad3C/p21 pathway (Yang, 2022)