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Montazeri says the effectiveness of the GLP-1 receptor agonist semaglutide for weight loss varies by person

Dual dynamics of mitochondrial permeability transition pore opening

Of special interest in this context are lipid peroxidation products, in particular 4-hydroxynonenal (HNE), which has been shown to both induce DNA damage [96] but also to be involved in the regulation of cell proliferation and growth as well as necrotic or apoptotic cell death by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression (for review see [97])

By eliminating tumor stem cell populations with high ALDH activity and combining with PARP inhibitors that target the bulk tumor cells, it can more thoroughly eradicate the tumor, prevent recurrence, and overcome PARP inhibitor resistance mediated by cancer stem cells (63).A similar mechanism is observed in its combination with doxorubicin