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483,484 The peptide p5RHH has been efficiently used to transfect siRNA and mRNA into human cartilage to reduce chondrocyte apoptosis and prevent cartilage degeneration 485,486,487 as well as into cardiac tissue for treating abdominal aortic aneurysm to reduce the risk of aortic rupture and sudden death in mice

Despite several constraints, PHH rank among the most representative models for human hepatocytes