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A higher intensity CHIMERA model, modCHIMERA, using two injury severity levels 1.7 and 2.1 joules, resulted in persistent neurobehavioral deficits, including decreased spontaneous behavior, spatial learning and memory deficits, and socialization at 1 month, as well as significant microglial activation in cortical and subcortical areas including hippocampus and lateral septal nucleus (LSN) and significant axonal injury manifested by increased -APP accumulation in the major white matter tracts including corpus callosum (CC), anterior commissure (AC), hippocampal commissure (HC), and fimbria (Sauerbeck et al., 2018)

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Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial