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Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation

Protein binding has little effect on the clearance of high-extraction drugs, as the liver's high metabolic capacity can efficiently remove the drug from binding proteins as it passes through

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However, in vitro, we did not find any indications for the non-enzymatic formation of apocarotenoid adducts, not even upon prolonged incubation in the presence of high molar excess of GSH and at alkaline pH conditions which are known to both strongly favor glutathionylation (Esterbauer et al