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Both peptides enhance cellular antioxidant systemsGHK-CU through direct antioxidant activity and Epithalon through gene expression modulationprotecting against oxidative stress and age-related damage

In this context, persistent ROS accumulation can overwhelm antioxidant capacity and has been linked to caspase-dependent gasdermin cleavage in mammary cancer cells 186-189

10.1523/JNEUROSCI.3667-12.2013 114 LiD.AgulhonC.SchmidtE.OheimM.RopertN

The reaction rate is influenced by the nucleophilicity of the thiolate, resulting in the enhanced capacity of NAC for reducing disulfide bonds compared to cysteine and GSH (Noszl et al., 2000)