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Cyclic vomiting syndrome phases Inter-episodic phase (feeling generally well) Prodrome (early symptoms without vomiting) Vomiting phase (nausea, vomiting and retching, abdominal pain) Recovery (slowly regain energy, hydrating and eating) This is important to understand as medications can be administered at the first sign of symptoms during the prodrome phase to stop or reduce symptoms of CVS from progressing to a full-blown episode

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Absorbance for all enzymatic analyses was measured using a Genesys 10S UV-Vis spectrophotometer (Thermo Scientific, USA)

Eur J Med Chem 44:32593265 Acknowledgments This project is supported by the Office of the Higher Education Commission, Mahidol University under the National Research Universities Initiative and Annual Government Grant of Mahidol University (25562558 B.E.)