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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with pembrolizumab and platinum chemotherapy, are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

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Skipped periods Not only can your cycle get much longer, you can also miss your period for an entire month, just to have it appear again the following month