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This hypothesis is based on the finding that women with endometriosis have a high level of gram-negative bacteria and the bacterial toxin lipopolysaccharide (LPS) in their pelvis ( 5 )

These advances led to remarkable discoveries in redox biology such as identifying mito- chondrial H 2 O 2 as a signal for hypoxia inducible factor-1 (HIF-1) pathway activation [ 5 ]

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In addition to adenosine receptor agonists and antagonists, drugs that target intracellular signaling moleculessuch as Ras proteins, G proteins, and the small GTPase Rhoare also being explored (94)