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Key Points One-carbon metabolism integrates cellular nutrient status by cycling carbon units from amino acid inputs to generate diverse outputs, including redox maintenance and cellular biosynthesis

Parkinsons disease is a neurological ailment that currently has no treatment

Because PFKFB3 is upregulated in EGFR-TKI resistant NSCLC, PFK15 exhibits synergistic impact with erlotinib in wild type and EGFR mutant cell lines (Lypova et al., 2019)

Studies have shown that there is a close relationship between the survival of the mitochondrial GSH pool (mGSH) and that of the cells due to the central role of mitochondria in programmed cell death (apoptosis) as well as important involvement of ROS produced at 90% in mitochondria [17]