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The following list provides guidelines for some of the most common uses, based largely on doses used in studies for these conditions: Fat metabolism (conversion of fat to energy) and muscular performance: 1,000 to 2,000 mg usually divided into two doses Heart disease: 600 to 1,200 mg three times daily, or 750 mg twice daily Alcohol-related carnitine deficiency: 300 mg three times daily Male infertility: 300 to 1,000 mg three times daily Chronic fatigue syndrome: 500 to 1,000 mg three to four times per day Overactive thyroid: 2,000 to 4,000 mg per day in two to four divided doses Precautions Because supplements may have side effects or interact with medications, they should be taken only under the supervision of a knowledgeable healthcare provider

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To account for potential pleiotropy, in each analysis, we used different analytic methods robust to pleiotropy, including Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), a weighted median, and weighted mode