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INH exposure (3 mM and 6 mM, 48 h) significantly impaired erythrocyte antioxidant defenses in a concentration-dependent manner by markedly reducing activity of SOD (Figure 4A), GPx (Figure 4B), and CAT (Figure 4C), providing direct experimental validation of the transcriptional dysregulation of their encoding genes predicted by HepG2 omics analysis, confirming the biological relevance of the identified OS pathways