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When treating the vessels, the pulsed dye laser decreases the stimulus to melanocytes and subsequently the recurrence of the spots

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Durvalumab or pembrolizumab combined with CisGem is already approved by the FDA and EMA in this indication and both are recommended by most national and international guidelines as first-line treatment in biliary tract cancer, especially taking into account that the 24-month survival rates in both studies are comparable (23.6% 308 versus 25% 310 , respectively)