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Description

FEBS Lett 554(3):417421

COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites

These should encompass well-designed in vitro and in vivo studies alongside large-scale, multicenter randomized controlled trials with extended follow-up periods, diverse patient populations, and standardized dosing and formulation strategies

This implies that direct RAPTORmembrane interaction is a general requirement for mTORC1 membrane engagement, whereas mTORmembrane interaction promotes full activation of the mTOR kinase