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In sum, rapamicyn and rapalogs inhibit mTORC1 as demonstrated in several in vitro experiments (160), though incomplete mTOR signaling occurs due to these drugs incapacity of inhibit mTORC2 too, and in consequence, it has been suggested that cancer cells could survive because of Akt activation, for this reason and aiming to replicate the successful results observed in cell lines to patients, it is imperative to evaluate the synergic effect of mTOR inhibitors with other drugs or treatments that have shown promising results in patients and also lead the inhibition of mTOR signaling by drugs to perform a complete inhibition of mTORC1 and mTORC2 in order to guarantee clinical outcome

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Oxidative stress occurs when the body has too many unstable molecules called pro-oxidants free radicals and reactive oxygen species (ROS)

Social interaction test performance in rats was assessed for 10 min in 90 days old rats by means of two parameters