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Reversal agents are safe and has no effects if administered to someone not experiencing an opioid overdose.(22) They are used to provide temporary relief from an overdose it is critical that anyone who has received a reversal agent for a suspected overdose be seen immediately in the emergency department or by ambulance personnel

Anyone can submit written comments electronically through regulations.gov or by mail

These studies on myocardial injury and the GSH system reveal new roles of these clinical drugs in the treatment and further elaborate their mechanisms, which provide new ideas for their clinical application

1-methyl-4-phenylpyridinium (MPP + ) was obtained from Cayman Chemicals (Ann Arbor, MI, USA)