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Keap1-Nrf2 Pathway and Autophagy The selective autophagy substrate p62 contains an ETGE-like motif, STGE, which could be phosphorylated by mTOR complex 1 to bind to Keap1 with higher affinity (Taguchi et al., 2012)

Coronavirus inhibits karyopherin-mediated nuclear import decreasing GSH production (Sims et al., 2013

The National Institutes of Health in the US have followed suit in prioritizing the development and use of human-relevant testing methods by stating that projects only encompassing animal studies will no longer be funded (219)