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Nrf2 has been demonstrated to affect BBB integrity by regulating the expression of BBB endothelial TJ proteins such as ZO-1 and OCLN (207)

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These associations raise the intriguing possibility that newly synthesized heme generated by FECH may be directly handed off to ABCB7 through the lipid bilayer for subsequent export

Bioenergetic studies Membrane potential studies were performed using Bac Light Bacterial Membrane Potential kit (Molecular Probes, Inc.) in accordance with manufacturer instructions