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This suppresses transcription of pro-inflammatory genes, reducing TNF-alpha production and IL-6 secretion

By the controlled release of ATRA/ATO and internalization of nanoparticles in cancer cells to overcome the defects of ATRA and ATO such as short half-life, poor water solubility and side effects, ATRA-ATO-NPs not only greatly enhance the anti-tumor efficacy of ATRA and ATO, but also are expected to greatly improve the safety of the two drugs in clinical practice

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However, in RSMC +/ , the accumulation of Sororin on chromatin was not so evident, especially before 5 h