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Proinflammatory factors, LPS, growth factors, and antigen receptors activate the IKK complex (including IKK, IKK, and NEMO), and the latter phosphorylates the IB protein, leading to ubiquitination and lysosomal degradation of IB, resulting in the release of NF-B

These results indicate that in the ovaries, CXCL10 binds to IL18R1 to induce downstream JNKJUN activation, which subsequently promotes the transcription of COL1A1 and ovarian fibrosis (Fig

10.1016/j.ijpharm.2020.119926 54 GomezL.SebastianV.IrustaS.IbarraA.ArrueboM.SantamariaJ

This is not a replacement for medical treatment but may complement general wellness routines