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Key Points Deferasirox is an oral iron chelator with nephrotoxic potential that could result in decreased glomerular filtration requiring dialysis and in proximal tubular dysfunction Although deferasirox nephrotoxicity has been reported to promote tubular cell injury, the molecular and cellular mechanisms are poorly understood Postmarketing monitoring of potential long-term effects of chronic deferasirox treatment on kidney function is required Careful selection and monitoring of patients treated with deferasirox might decrease the risks of serious renal adverse effects Abstract In 2005, the oral iron chelator deferasirox was approved by the FDA for clinical use as a first-line therapy for blood-transfusion-related iron overload

The team also saw no decline in heart or lung function, suggesting the issue with fatigue is not originating in those organs

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Cagrilintide has progressed through multiple phases of clinical research , with ongoing studies continuing to evaluate its biological activity, pharmacokinetics, and long-term effects