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Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells

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Wang W, Kryczek I, Dostal L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W (2016) Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer

Meanwhile, tumor cells can increase FAO levels by upregulating CPT1 expression, and high levels of FAO can promote EMT [100, 132, 133] and foster M2 macrophage polarization, which subsequently leads to the secretion of pro-inflammatory cytokines such as IL-1, thereby augmenting tumor cell motility and proliferative capacity [134]