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The present study using LC-MS technology also highlights significant changes in various metabolites that have not previously been analyzed as part of frog overwintering but may be interesting targets for further research in the field

Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1

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Eight DEGs involving proteins were presented in purine/pyrimidine metabolism, among which the nucleoside diphosphate kinase (Ndk) is a housekeeping enzyme that functions to balance the cellular nucleoside triphosphate pool and was believed to regulate microbial virulence [72], showed a value of log2FC 2.80 at 3 DPI vs CK (Additional file 1: Dataset S1)