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Several complex I inhibitors have been evaluated clinically and discontinued due to neurotoxicity and adverse side effects (IACS-010759, Tamoxifen, Piericidin A, Phenformin) (76, 77)

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NAD+ Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme involved in hundreds of cellular reactions

Horm Metab Res 33 : 156162 Scavo LM et al